Adenoviral Vectors for Gene Therapy

Number of page: 890
Author: edited by David T. Curiel, Joanne T. Douglas
Publisher: Academic Press
Rating:
Category: Science

Adenoviral Vectors for Gene Therapy provides detailed and comprehensive coverage of these important therapeutic agents. The topics covered in this book range from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology and the use of adenoviral vectors in preclinical animal models, to regulatory issues which must be considered prior to the initiation of human clinical gene therapy trials. The broad scope of this unique volume provides the reader with a complete understanding of the development and use of adenoviral vectors.Key Features* Provides complete coverage of basic biology of adenoviruses, as well as the construction, propagation and purification of adenoviral vectors* Introduces common strategies for the development of adenoviral vectors along with cutting-edge methods for their improvement* Demonstrates noninvasive imaging of adenovirus-mediated gene transfer* Discusses utility of adenoviral vectors in animal disease models* Considers Federal Drug Administration regulations for human clinical trials

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About The Author

David T. Curiel, M.D., Ph.D. is the Director of the Cancer Biology Division of the Department of Radiation Oncology at Washington University School of Medicine. Dr. Curiel graduated medical school at Emory University in 1982, where he also completed his internship and residency in Internal Medicine. Dr. Curiel’s scientific training includes tenureship at the National Institutes of Health in Bethesda, Maryland at the Pulmonary Branch of the Heart and Lung, and Blood Institute (NHLBI) from 1985-1989, and a fellowship in Biotechnology at the National Cancer Institute, Navy Medical Oncology Branch from 1989-1990. He received his Ph.D. from University of Groningen in The Netherlands in 2002. Dr. Curiel has been at Washington University School of Medicine since 2011. In addition to his role as Director of the Cancer Biology Division, he is Director of the Biologic Therapeutics Center.